PharmaGuide 4.3.1.4

Instant and Predictive Search by:

• Brand
• Generic Name (e.g. Cefoperazone)
• Contents (e.g. Cefoperazone and Sulbactam)
• Therapeutic Category (e.g. Cephalosporins)

Interaction Checker:

• The Interaction Checker feature allows for the quick identification of interactions among prescribed drugs.
• You can select generics as well as brands in your country to check interactions.

Risk Factors

Information under Risk Factors includes Contraindications, Precautions, and Risks in Pregnancy and Lactation for the relevant product.

Pregnancy: Risk cannot be ruled out.

Lactation: Contraindicated.

Contraindications: Severe respiratory depression; severe obstructive lung conditions.

Precautions: COPD, raised intracranial pressure, impaired consciousness, head injury, bradyarrhythmia, renal or hepatic impairment. Monitor for signs of respiratory depression. Brain tumor. Risk of tolerance and dependence. Elderly or debilitated patients.

Dosage (Along with Indications)

Fast, Quick & Easy Access to Accurate Dosage in Specific Indications

The usual dosages are:

• Adults: Usually 1 gm daily by deep IM, slow IV injection over at least 2-4 min, or IV infusion. For severe infections, 2-4 gm as a single dose every 24 hrs.
• Children: Usually 20-50 mg/kg once daily by IM injection, slow IV injection over at least 2-4 min, or IV infusion. For severe infections, up to a maximum of 80 mg/kg daily. Doses over 50 mg/kg should be given by slow IV infusion over at least 30 minutes.
• Neonates: IM/IV: Postnatal age ≤ 7 days or > 7 days (body wt ≤ 2 Kg): 50 mg/kg/day given every 24 hrs. Postnatal age > 7 days, body wt > 2 Kg: 50-75 mg/kg/day given every 24 hrs.

Administration

How to prepare and administer e.g., an Injectable

• The drug may be administered by IV intermittent infusion over 10-30 min; the final concentration for IV administration should not exceed 40 mg/mL. The drug has also been administered by direct IV push over 2-4 min. Inject deep IM into a large muscle mass.
• IM Injection: Dilute VIAL concentrations accordingly.
• IV: Dilute VIAL concentrations accordingly.

Compatibility: Stable in D5W, D10W, NS, Sodium bicarbonate 5%, bacteriostatic water, SWFI.

Stability: For IV infusion in NS or D5W, the solution is stable for a specified duration at room temperature or refrigerated conditions.

Interactions

The drug may interact with:

• Amikacin
• Aminoglycosides
• Anticoagulants
• Gentamicin
• Kanamycin
• Neomycin
• Netilmicin
• Streptomycin
• Tobramycin
• Warfarin

Adverse Effects

• GI upset
• Skin reactions
• Blood dyscrasias
• Rarely pseudomembranous colitis
• Raised liver enzymes
• Glycosuria
• Oliguria
• Haematuria
• Bronchospasm
• Phlebitis at the injection site
• Urinary and biliary precipitates
• Pancreatitis

Alternate Products

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